US Patent Issued to CNPharm on Sept. 9 for "Synthesizing drug-organic-acid-anhydride conjugates without using coupling reagent" (South Korean Inventors)

ALEXANDRIA, Va., Sept. 10 -- United States Patent no. 12,409,229, issued on Sept. 9, was assigned to CNPharm Co. Ltd. (Seoul, South Korea).

"Synthesizing drug-organic-acid-anhydride conjugates without using coupling reagent" was invented by Hojun Kim (Seoul, South Korea), Kwang Sik Park (Seoul, South Korea) and Guen-Woo Jin (Seoul, South Korea).

According to the abstract* released by the U.S. Patent & Trademark Office: "Synthesizing a drug-organic-acid-anhydride conjugate using docetaxel as a drug, including: mixing aconitic anhydride with a chlorinating reagent to produce a first mixture; dissolving the first mixture in an organic solvent to produce a dissolved mixture; stirring the dissolved mixture; evaporating the organic solvent from...