ALEXANDRIA, Va., June 10 -- United States Patent no. 12,291,708, issued on May 6, was assigned to CiVi Biopharma Inc. (Chevy Chase, Md.).

"Oral delivery of antisense conjugates targeting PCSK9" was invented by Henrik Oerum (Copenhagen, Denmark), Stewart Alwyn Noble (San Diego) and Charles Lester Shear (Collegeville, Pa.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure provides pharmaceutic compositions for oral delivery comprising an antisense oligonucleotide (e.g., CIVI 008) and an oral delivery agent such as 5-CNAC. In some aspects, the disclosure provides a capsule comprising a dry blend of CIVI 008 and 5-CNAC, and optionally a statin."

The patent was filed on Dec. 10, 2021, under Ap...