ALEXANDRIA, Va., Sept. 10 -- United States Patent no. 12,410,432, issued on Sept. 9, was assigned to CITY UNIVERSITY OF HONG KONG (Kowloon, Hong Kong).
"L-RNA aptamer cyclization and use thereof" was invented by Chun Kit Kwok (Kowloon, Hong Kong) and Danyang Ji (Kowloon, Hong Kong).
According to the abstract* released by the U.S. Patent & Trademark Office: "A method of cyclizing an L-RNA aptamer by modifying the aptamer with a 3' azide and a 5' alkyne group and using click chemistry reaction-based method. The cyclized L-RNA aptamers have improved binding properties and favour more in vitro/cell applications. Also disclosed is an L-oligonucleotide aptamer having linked ends."
The patent was filed on April 21, 2021, under Application No. 1...