US Patent Issued to Circular Commitment on July 29 for "Therapeutic biologic for treatment of hepatocellular carcinoma" (American, Taiwanese Inventors)

ALEXANDRIA, Va., July 30 -- United States Patent no. 12,371,473, issued on July 29, was assigned to Circular Commitment Co. (Taipei, Taiwan).

"Therapeutic biologic for treatment of hepatocellular carcinoma" was invented by Kuo-Jang Kao (Gainesville, Fla.) and Yun-Hsin Wang (Taipei, Taiwan).

According to the abstract* released by the U.S. Patent & Trademark Office: "The invention provides conjugates comprising a coagulating agent conjugated to an antibody, where the antibody specifically binds an extracellular domain epitope of a mammalian PLVAP protein. These agents specifically target HCC tumors and treat the HCC. The invention also provides methods of using these conjugates, such as methods of treating HCC by administering the conjugate...