US Patent Issued to CHUGAI SEIYAKU on Sept. 9 for "Cyclic compound having selective KRAS inhibitory effect on HRAS and NRAS" (Japanese Inventors)

ALEXANDRIA, Va., Sept. 10 -- United States Patent no. 12,410,212, issued on Sept. 9, was assigned to CHUGAI SEIYAKU K.K. (Tokyo).

"Cyclic compound having selective KRAS inhibitory effect on HRAS and NRAS" was invented by Hatsuo Kawada (Kamakura, Japan), Koji Takano (Kamakura, Japan), Tomoya Kotake (Gotemba, Japan), Mirai Kage (Gotemba, Japan), Satoshi Hashimoto (Gotemba, Japan), Minoru Tamiya (Kamakura, Japan), Yuma Wakamiya (Kamakura, Japan), Ryuji Hayashi (Kamakura, Japan) and Yuya Morita (Kamakura, Japan).

According to the abstract* released by the U.S. Patent & Trademark Office: "Cyclic compounds that selectively inhibit KRAS were found. Moreover, cyclic compounds were found to interact with an amino acid residue specific to KRAS."

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