US Patent Issued to Chugai Seiyaku on Sept. 23 for "Antibody variant and isoform with lowered biological activity" (Japanese Inventors)

ALEXANDRIA, Va., Sept. 23 -- United States Patent no. 12,421,322, issued on Sept. 23, was assigned to Chugai Seiyaku K.K. (Tokyo).

"Antibody variant and isoform with lowered biological activity" was invented by Kensaku Hosoguchi (Tokyo), Maki Kuwayama (Tokyo), Chifumi Seida (Tokyo), Yosuke Watanabe (Tokyo), Nobuyuki Tanaka (Tokyo), Satoshi Saitoh (Tokyo) and Masakazu Fukuda (Tokyo).

According to the abstract* released by the U.S. Patent & Trademark Office: "As antibody variants and isoforms having reduced FVIII mimetic activity than Emicizumab, the antibody variants having some specific amino acid residues in the variable region cleaved out and missing (Q-CDR-Clipped Variants) and the antibody isoforms having inter-heavy chain disulfide b...