US Patent Issued to Chugai Seiyaku on Nov. 25 for "Cytotoxicity-inducing therapeutic agent" (Japanese Inventors)

ALEXANDRIA, Va., Nov. 25 -- United States Patent no. 12,479,929, issued on Nov. 25, was assigned to Chugai Seiyaku K.K. (Tokyo).

"Cytotoxicity-inducing therapeutic agent" was invented by Junichi Nezu (Shizuoka, Japan), Takahiro Ishiguro (Kanagawa, Japan), Atsushi Narita (Shizuoka, Japan), Akihisa Sakamoto (Shizuoka, Japan), Yumiko Kawai (Kanagawa, Japan), Tomoyuki Igawa (Shizuoka, Japan) and Taichi Kuramochi (Shizuoka, Japan).

According to the abstract* released by the U.S. Patent & Trademark Office: "Disclosed are antibodies with heavy chain constant regions having the sequence of an IgG1 constant region with one or more mutations including one or more substitutions that reduce the ability of the heavy chain constant regions to bind to a...