US Patent Issued to Chugai Seiyaku on July 15 for "Method for producing polypeptide hetero-oligomer" (Japanese Inventors)

ALEXANDRIA, Va., July 16 -- United States Patent no. 12,359,001, issued on July 15, was assigned to Chugai Seiyaku K.K. (Tokyo).

"Method for producing polypeptide hetero-oligomer" was invented by Tomoyuki Igawa (Shizuoka, Japan), Hitoshi Katada (Shizuoka, Japan), Yuji Hori (Shizuoka, Japan) and Shojiro Kadono (Kanagawa, Japan).

According to the abstract* released by the U.S. Patent & Trademark Office: "It is intended to provide a method for efficiently and stably producing a heteromultimer by incubating homo variants of plural types of heavy chain constant region-containing polypeptides differing in antigen-binding activity under a reducing condition that reorganize the inter-polypeptide disulfide bond between cysteine residues outside of...