US Patent Issued to Chugai Seiyaku on Dec. 30 for "Antigen-binding molecule comprising altered antibody variable region" (Singaporean, Japanese Inventors)

ALEXANDRIA, Va., Dec. 31 -- United States Patent no. 12,509,524, issued on Dec. 30, was assigned to Chugai Seiyaku K.K. (Tokyo).

"Antigen-binding molecule comprising altered antibody variable region" was invented by Tomoyuki Igawa (Singapore), Shu Feng (Singapore), Shu Wen Samantha Ho (Singapore) and Hirotake Shiraiwa (Shizuoka, Japan).

According to the abstract* released by the U.S. Patent & Trademark Office: "An antigen-binding molecule capable of binding to multiple different antigens (e.g., CD3 on T cells, and CD137 on T cells, NK cells, DC cells, and/or the like), but does not nonspecifically crosslink two or more immune cells such as T cells is provided. Such multispecific antigen-binding molecule is capable of modulating and/or act...