ALEXANDRIA, Va., Feb. 19 -- United States Patent no. 12,226,476, issued on Feb. 18, was assigned to CHINA PHARMACEUTICAL UNIVERSITY (Jiangsu, China).

"Helper epitope peptide and application thereof" was invented by Wenbing Yao (Jiangsu, China), Hong Tian (Jiangsu, China), Yi Xu (Jiangsu, China), Yu He (Jiangsu, China) and Xiangdong Gao (Jiangsu, China).

According to the abstract* released by the U.S. Patent & Trademark Office: "A helper epitope peptide is obtained by means of replacing one or two amino acid residues in the helper T cell epitope PADRE with 4-nitrophenylalanine. The helper epitope peptide is effective for enhancing the immunogenicity of an antigen or antigenic epitope or for preparing or constructing a vaccine, and a fusion...