US Patent Issued to Children's Medical Center on April 29 for "Saposin-A derived peptides and uses thereof" (Massachusetts Inventor)

ALEXANDRIA, Va., June 9 -- United States Patent no. 12,285,459, issued on April 29, was assigned to Children's Medical Center Corp. (Boston).

"Saposin-A derived peptides and uses thereof" was invented by Randolph S. Watnick (Newton, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Disclosed herein are polypeptides and fusion polypeptides that have anti-angiogenic activity that can be used to inhibit tumor growth and tumor metastasis. The polypeptide consists of 9 or less consecutive amino acid residues (e.g., 8, 7, 6, 5, or 4) comprising the active core amino acid sequence DWLP, or an amino acid substitution variant thereof. Specific amino acid substitutions are disclosed herein. In some embodiments, the...