US Patent Issued to Children's Hospital Medical Center on March 25 for "Methods and systems for converting precursor cells into intestinal tissues through directed differentiation" (Ohio, Michigan, Texas Inventors)

ALEXANDRIA, Va., March 26 -- United States Patent no. 12,258,584, issued on March 25, was assigned to Children's Hospital Medical Center (Cincinnati).

"Methods and systems for converting precursor cells into intestinal tissues through directed differentiation" was invented by James M. Wells (Cincinnati), Aaron M. Zorn (Cincinnati), Jason R. Spence (Ann Arbor, Mich.) and Noah F. Shroyer (Houston).

According to the abstract* released by the U.S. Patent & Trademark Office: "The generation of complex organ tissues from human embryonic and pluripotent stem cells (PSCs) remains a major challenge for translational studies. It is shown that PSCs can be directed to differentiate into intestinal tissue in vitro by modulating the combinatorial activ...