ALEXANDRIA, Va., June 6 -- United States Patent no. 12,281,148, issued on April 22, was assigned to Cephalon LLC.

"Anti-pd-1 antibody-attenuated IL-2 immunoconjugates and uses thereof" was invented by David S. Wilson Jr. (Redwood City, Calif.), Kim Tran Yap (Atherton, Calif.), Paul Ayton (San Francisco), Debasish Sen (Redwood City, Calif.), Julia Rozenfeld (Gordon, Australia), Sachin Badrinath Surade (Macquarie Park, Australia) and Anthony Gerard Doyle (Macquarie Park, Australia).

According to the abstract* released by the U.S. Patent & Trademark Office: "Disclosed herein are modified human interleukin-2 (hIL-2) proteins, human antibody molecules, or antigen-binding fragments thereof, that immunospecifically bind to human programmed cell ...