US Patent Issued to Central Institute for Experimental Animals on Sept. 30 for "Immunodeficient mouse" (Japanese Inventors)

ALEXANDRIA, Va., Sept. 30 -- United States Patent no. 12,426,579, issued on Sept. 30, was assigned to Central Institute for Experimental Animals (Kanagawa, Japan).

"Immunodeficient mouse" was invented by Takeshi Takahashi (Kanagawa, Japan) and Ikumi Katano (Kanagawa, Japan).

According to the abstract* released by the U.S. Patent & Trademark Office: "An object of the present invention is to provide an immunodeficient mouse which is capable of eliminating effects of immune cells from the immunodeficient mouse against human antibodies and in which human cells are engrafted at high level.Deletion of a mouse FcgR gene from an NOG mouse results in a mouse that does not exhibit antibody-dependent cellular cytotoxic activity on tumors, and in the...