US Patent Issued to CELLURIS on Dec. 9 for "Bispecific in tandem receptor car and method for modulating the tumoral microenvironment" (Brazilian Inventor)

ALEXANDRIA, Va., Dec. 9 -- United States Patent no. 12,491,247, issued on Dec. 9, was assigned to CELLURIS LLC (Lewes, Del.).

"Bispecific in tandem receptor car and method for modulating the tumoral microenvironment" was invented by Patricia Bortman Rozenchan (Sao Paulo).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention refers to a bispecific in tandem receptor CAR, named RfuCAR, which includes a scFv that recognizes and ligates surface molecules on tumoral cells (CD33, CD123 or another tumoral target) and the IL-1 receptor type 2 (IL-1R2). According to this, the IL1-R2 was chosen as the ideal receptor to compose the RfuCAR construction, being able to capture the IL-1Beta with high affinity...