US Patent Issued to Cellectis on July 22 for "Method for improving production of car T cells" (American, French Inventors)

ALEXANDRIA, Va., July 23 -- United States Patent no. 12,365,733, issued on July 22, was assigned to Cellectis (Paris).

"Method for improving production of car T cells" was invented by Alex Boyne (Jersey City, N.J.), Laurent Poirot (Paris), Philippe Duchateau (Draveil, France) and Alexandre Juillerat (New York).

According to the abstract* released by the U.S. Patent & Trademark Office: "A method for engineering less alloreactive immune cells, including T-cells that express chimeric antigen receptors (CARs), using a nucleotide sequence in form of an RNA encoding a anti-TCR CAR to achieve the transient expression of anti-TCR CAR at the cell surface. The transient expression of the anti-TCR CAR recognized by the alpha beta TCR on the cell sur...