ALEXANDRIA, Va., Feb. 19 -- United States Patent no. 12,227,519, issued on Feb. 18, was assigned to CELGENE Corp. (Summit, N.J.).
"Preparation of maytansinol" was invented by John Fitzgerald Traverse (Lebonon, N.J.), Nareshkumar Jain (Flemington, N.J.), Srinath Thirumalairajan (Bensalem, Pa.) and Sanjeevani Ghone (Plainsboro, N.J.).
According to the abstract* released by the U.S. Patent & Trademark Office: "A scaled process of preparing maytansinol, FORMULA II, is provided by reacting a compound of Formula I, wherein R is selected from the group consisting essentially of alkyl, branched alkyl, aryl, alkenyl, alkynyl, as well as substituted variations thereof, with at least one organometallic reagent to produce the compound of Formula II; ...