US Patent Issued to Cedars-Sinai Medical Center on March 25 for "Methods and compositions for inducible expression of neurotrophic factors" (California Inventors)

ALEXANDRIA, Va., March 26 -- United States Patent no. 12,258,571, issued on March 25, was assigned to Cedars-Sinai Medical Center (Los Angeles).

"Methods and compositions for inducible expression of neurotrophic factors" was invented by Clive Svendsen (Pacific Palisades, Calif.), Joshua Breunig (Los Angeles) and Aslam Akhtar (Torrance, Calif.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Delivery of glial cell line-derived neurotrophic factor (GDNF) has provided benefits to Parkinsonian patients and is currently being tested in a Phase 1/2a clinical trial for ALS patients. However, chronic trophic factor delivery prohibits dose adjustment or shut off in the event of side effects. To address this, the Invent...