US Patent Issued to Case Western Reserve University on May 27 for "Rapid-acting insulin analogues of enhanced stability" (Ohio Inventor)

ALEXANDRIA, Va., June 17 -- United States Patent no. 12,312,390, issued on May 27, was assigned to Case Western Reserve University (Cleveland).

"Rapid-acting insulin analogues of enhanced stability" was invented by Michael A. Weiss (Moreland Hills, Ohio).

According to the abstract* released by the U.S. Patent & Trademark Office: "A two-chain insulin analogue contains a modified A-chain polypeptide and a modified B-chain polypeptide. The A-chain polypeptide comprises one or more of: a His or Glu substitution at position A8, a Glu substitution at position A14; and a Gln or Arg substitution at position A17. The B-chain polypeptide comprises one or more of: a deletion of the amino acids at position B1, B1-B2, B1-B3, B30 or a combination there...