ALEXANDRIA, Va., June 4 -- United States Patent no. 12,319,726, issued on June 3, was assigned to CASE WESTERN RESERVE UNIVERSITY (Cleveland).
"Method for treating CD40-mediated diseases" was invented by Carlos Subauste (Cleveland) and Cecilia Subauste (Cleveland).
According to the abstract* released by the U.S. Patent & Trademark Office: "A cell-permeable polypeptide includes a membrane transduction domain and a polypeptide comprising an amino acid sequence substantially homologous to the amino acid sequence of the TRAF2,3 binding domain, the cell permeable peptide inhibiting binding of TRAF2 to the TRAF2,3 binding domain of CD40 to decrease or inhibit a CD-40 activity or signal transduction pathway associated with a CD40-mediated diseas...