US Patent Issued to CANCER THERAPEUTICS LABORATORIES on March 25 for "Humanized anti-nuclear antibodies for targeting necrosis in cancer therapy" (California Inventors)

ALEXANDRIA, Va., March 26 -- United States Patent no. 12,258,421, issued on March 25, was assigned to CANCER THERAPEUTICS LABORATORIES INC. (Los Angeles).

"Humanized anti-nuclear antibodies for targeting necrosis in cancer therapy" was invented by Alan Epstein (Los Angeles) and Peisheng Hu (Los Angeles).

According to the abstract* released by the U.S. Patent & Trademark Office: "Humanized monoclonal anti-nuclear antibodies with enhanced binding affinity and tumor uptake are presented. Particularly preferred antibodies are site-directed mutants of H-CDR3 with up to about 8-fold improvement in affinity as compared to the non-humanized non-mutated form. In further preferred aspects, such humanized antibodies are employed in tumor necrosis ta...