US Patent Issued to Brown University on Oct. 7 for "Quantifying cell-derived changes in collagen synthesis, alignment, and mechanics in a 3D connective tissue model" (Massachusetts Inventors)

ALEXANDRIA, Va., Oct. 8 -- United States Patent no. 12,435,312, issued on Oct. 7, was assigned to Brown University (Providence, R.I.).

"Quantifying cell-derived changes in collagen synthesis, alignment, and mechanics in a 3D connective tissue model" was invented by Jeffrey R. Morgan (Sharon, Mass.) and Benjamin T. Wilks (Boston).

According to the abstract* released by the U.S. Patent & Trademark Office: "Described herein are in vitro quantitative methods directed to 3D extracellular matrix (ECM) organization and mechanics. The methods do not require application of an external force, anchorage, or a scaffolding material in order to culture ECM tissue constructs, and the methods enable quantitative measurements without crosstalk noise from ...