US Patent Issued to Bristol-Myers Squibb on Oct. 28 for "Substituted piperazine derivatives useful as T cell activators" (American, Indian Inventors)

ALEXANDRIA, Va., Oct. 28 -- United States Patent no. 12,454,531, issued on Oct. 28, was assigned to Bristol-Myers Squibb Co. (Princeton, N.J.).

"Substituted piperazine derivatives useful as T cell activators" was invented by Upender Velaparthi (Princeton Junction, N.J.), Chetan Padmakar Darne (Ewing, N.J.), Richard E. Olson (Cambridge, Mass.) and Jayakumar Sankara Warrier (Bangalore, India).

According to the abstract* released by the U.S. Patent & Trademark Office: "Disclosed are compounds of Formula (I): or a salt thereof, wherein: R1, R2, R4, R5, R6, and m are defined herein. Also disclosed are methods of using such compounds to inhibit the activity of one or both of diacylglycerol kinase alpha (DGKAlpha) and diacylglycerol kinase zeta ...