ALEXANDRIA, Va., Nov. 18 -- United States Patent no. 12,474,298, issued on Nov. 18, was assigned to Bristol-Myers Squibb Co. (Princeton, N.J.).
"Isoelectric focusing sample matrix" was invented by Xin Zhang (Newton, Mass.), Letha Chemmalil (Devens, Mass.), Julia Ding (Weston, Mass.) and Zhengjian Li (Sudbury, Mass.).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure provides icIEF sample matrices that enable icIEF analysis of PEGylated proteins in their real conjugated states. The sample matrices of the present disclosure can include glycine, which enables the separation of co-migrated PEGylated protein charge variants. The sample matrices can also include taurine, which further improves ic...