US Patent Issued to Bristol-Myers Squibb on Dec. 9 for "Macrocyclic PAD4 inhibitors useful as immunosuppressant" (New Jersey, Pennsylvania Inventors)

ALEXANDRIA, Va., Dec. 9 -- United States Patent no. 12,492,202, issued on Dec. 9, was assigned to Bristol-Myers Squibb Co. (Princeton, N.J.).

"Macrocyclic PAD4 inhibitors useful as immunosuppressant" was invented by Khehyong Ngu (Pennington, N.J.), Christopher Annunziato (North Lawrence, N.J.), John V. Duncia (Newtown, Pa.) and Daniel S. Gardner (Furlong, Pa.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention provides compounds of Formula (I) useful as inhibitors of PAD4, compositions thereof, and methods of treating PAD4-related disorders, (I) wherein ring A, A1, A2, A3, A4, Q, R1, R2, R3, R4, R5, and R6 along with other variables are as defined herein."

The patent was filed on Feb. 5, 20...