US Patent Issued to Breye Therapeutics on Feb. 10 for "Heterocyclic derivatives as P2X7 receptor antagonists" (Italian, Polish Inventors)

ALEXANDRIA, Va., Feb. 11 -- United States Patent no. 12,545,682, issued on Feb. 10, was assigned to Breye Therapeutics ApS (Horsholm, Denmark).

"Heterocyclic derivatives as P2X7 receptor antagonists" was invented by Paolo Pevarello (Bresso, Italy), Mariangela Sodano (Bresso, Italy), Valentina Cusano (Bresso, Italy), Francesco Piscitelli (Bresso, Italy), Domenica Torino (Bresso, Italy), Rocco Vitalone (Bresso, Italy), Ali Munaim Yousif (Bresso, Italy) and Oleksii Artamonov (Cracow, Poland).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention relates to novel 1,4-substituted piperidine compounds of formula (I) having P2X7 receptor (P2X7) antagonistic properties, pharmaceutical compositions compr...