ALEXANDRIA, Va., Sept. 30 -- United States Patent no. 12,428,644, issued on Sept. 30, was assigned to BRACCO IMAGING S.P.A. (Milan).
"CA-IX aptamers and diagnostic and therapeutic uses thereof" was invented by Vittorio De Franciscis (Naples, Italy), Carla Lucia Esposito (Naples, Italy), Silvia Catuogno (Naples, Italy), Silvia Nuzzo (Salerno, Italy), Alessandro Maiocchi (Monza, Italy), Margherita Iaboni (Qualiano, Italy), Aldo Di Vito (Naples, Italy), Erika Reitano (Banchette, Italy) and Luisa Poggi (Banchette d'Ivrea, Italy).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention provides nucleic acid aptamers binding to the Carbonic Anhydrase IX (CA-IX) enzyme, derivatives and conjugates thereof...