ALEXANDRIA, Va., Aug. 20 -- United States Patent no. 12,390,508, issued on Aug. 19, was assigned to Boehringer Ingelheim International GmbH (Germany).
"Brain natriuretic peptide engrafted antibodies" was invented by Damian Brockschnieder (Haan, Germany), Jan Tebbe (Cologne, Germany), Andreas Wilmen (Cologne, Germany) and Frank Wunder (Wuppertal, Germany).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention relates to an antibody or a fragment thereof comprising at least one heterologous amino acid sequence incorporated within at least one CDR region of said antibody or fragment thereof, wherein said at least one heterologous amino acid sequence comprises an N-terminal linker sequence (Ntls), a...