ALEXANDRIA, Va., Nov. 6 -- United States Patent no. 12,460,198, issued on Nov. 4, was assigned to BioNTech SE (Mainz, Germany).
"Method for reducing immunogenicity of RNA" was invented by Katalin Kariko (Rydal, Pa.) and Ugur Sahin (Mainz, Germany).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention relates to RNA therapy and, in particular, decreasing immunogenicity of RNA. Specifically, the present invention provides methods for decreasing immunogenicity of RNA, said methods comprising modifying the nucleotide sequence of the RNA by reducing the uridine (U) content, wherein said reduction of the U content comprises an elimination of U nucleosides from the nucleotide sequence of the RNA and/o...