ALEXANDRIA, Va., July 30 -- United States Patent no. 12,371,480, issued on July 29, was assigned to BIOMOLECULAR HOLDINGS LLC (Burlingame, Calif.).
"Peptide-hinge-free flexible antibody-like molecule" was invented by Daniel J. Capon (Hillsborough, Calif.).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention provides an antibody that can bind to targets with greater affinity. A flexible antibody-like molecule having a nonpeptide hinge part comprising: a group having a nonpeptide hinge part represented by a general formula (I): XY-Asp-Lys-Thr-His-Thr (SEQ ID No. 1)- wherein X represents an amino acid or a peptide composed of 2 to 50 amino acid residues, and Y represents for a group having an alk...