ALEXANDRIA, Va., Aug. 6 -- United States Patent no. 12,378,524, issued on Aug. 5, was assigned to Biomet Manufacturing LLC (Warsaw, Ind.).
"Methods of mediating macrophage phenotypes" was invented by Jennifer E. Woodell-May (Warsaw, Ind.), Joel C. Higgins (Claypool, Ind.) and William King (Warsaw, Ind.).
According to the abstract* released by the U.S. Patent & Trademark Office: "Methods of inducing a polarization of macrophages. The method includes obtaining a blood fraction, fractionating the blood fraction to produce a blood fraction, and contacting the blood fraction with a source of macrophages. A blood fraction including platelet-poor plasma polarizes the source of macrophages into M1 macrophages. A blood faction including a protein ...