US Patent Issued to Biohaven Therapeutics on May 13 for "Method for synthesizing furoimidazopyridine compound, polymorphic substance and polymorphic substance of salt" (Chinese, American Inventors)

ALEXANDRIA, Va., June 12 -- United States Patent no. 12,297,206, issued on May 13, was assigned to Biohaven Therapeutics Ltd. (Tortola, British Virgin Islands).

"Method for synthesizing furoimidazopyridine compound, polymorphic substance and polymorphic substance of salt" was invented by Congxin Liang (Jupiter, Fla.), Laibao Wang (Shanghai) and Haihui Liu (Shanghai).

According to the abstract* released by the U.S. Patent & Trademark Office: "A method for synthesizing a compound 2-[(2R,5S)-5-[2-methylfuro[3,2-b]imidazo[4,5-d]pyridin-1-yl]tetrahydropyran-2-yl]acetonitr ile as a selective JAK1/TYK2 kinase inhibitor. The compound is prepared by taking 7-chloro-6-nitrofuro[3,2-b]pyridine as the starting material, and by nucleophilic substituti...