ALEXANDRIA, Va., Oct. 8 -- United States Patent no. 12,435,107, issued on Oct. 7, was assigned to BicycleTx Ltd. (Cambridge, Great Britain).
"Heterotandem bicyclic peptide complex" was invented by Gemma Mudd (Lexington, Mass.), Punit Upadhyaya (Lexington, Mass.), Kevin McDonnell (Cambridge, Great Britain) and Johanna Lahdenranta (Lexington, Mass.).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention relates to a heterotandem bicyclic peptide complex which comprises a first peptide ligand, which binds to Nectin-4, conjugated via a linker to two second peptide ligands, which bind to CD137. The invention also relates to the use of said heterotandem bicyclic peptide complex in preventing, suppress...