ALEXANDRIA, Va., July 9 -- United States Patent no. 12,350,343, issued on July 8, was assigned to BicycleTx Ltd. (Cambridge, Great Britain).
"Bicyclic peptide ligands specific for MT1-MMP" was invented by Catherine Stace (Cambridge, Great Britain), Daniel Teufel (Cambridge, Great Britain) and Edward Walker (Cambridge, Great Britain).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention relates to polypeptides which are covalently bound to non-aromatic molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of membrane type 1 metalloprotease (MT1-MMP), such as ...