ALEXANDRIA, Va., June 4 -- United States Patent no. 12,318,454, issued on June 3, was assigned to BicycleRD Ltd. (Cambridge, Great Britain).

"Bicyclic peptide ligands specific for MT1-MMP" was invented by Daniel Paul Teufel (Cambridge, Great Britain), Catherine Lucy Stace (Cambridge, Great Britain), Silvia Pavan (Cambridge, Great Britain), Edward Walker (Cambridge, Great Britain) and Leonardo Baldassarre (Cambridge, Great Britain).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides...