US Patent Issued to Beam Therapeutics on Oct. 28 for "Compositions and methods for improving base editing" (Massachusetts Inventors)

ALEXANDRIA, Va., Oct. 28 -- United States Patent no. 12,454,694, issued on Oct. 28, was assigned to Beam Therapeutics Inc. (Cambridge, Mass.).

"Compositions and methods for improving base editing" was invented by John Evans (Cambridge, Mass.) and Jason Michael Gehrke (Cambridge, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The invention features compositions and methods for modifying a polynucleotide (e.g., DNA) using a nucleobase editor comprising a first DNA binding protein domain that is catalytically inactive, a domain having base editing activity, and a second DNA binding protein domain having nickase activity. The invention also features a fusion protein comprising a domain having base editing ...