US Patent Issued to Beam Therapeutics on Jan. 20 for "Compositions and methods for delivering a nucleobase editing system" (Massachusetts Inventor)

ALEXANDRIA, Va., Jan. 20 -- United States Patent no. 12,529,041, issued on Jan. 20, was assigned to Beam Therapeutics Inc. (Cambridge, Mass.).

"Compositions and methods for delivering a nucleobase editing system" was invented by David Bryson (Cambridge, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The invention provides compositions and methods for delivering first and second polynucleotides each encoding a fragment of an A-to-G Base Editor fusion protein comprising one or more deaminases (e.g., adenosine deaminases) and nCas9, wherein the first polynucleotide encodes an N-terminal fragment of nCas9 fused to an intein-N of a split intein pair and the second polynucleotide encodes a C-terminal fragmen...