US Patent Issued to Baylor College of Medicine on Aug. 5 for "Reprogramming CD4 t cells into cytotoxic CD8 cells by forced expression of CD8ab and class 1 restricted t cell receptors" (Texas Inventors)

ALEXANDRIA, Va., Aug. 6 -- United States Patent no. 12,377,147, issued on Aug. 5, was assigned to Baylor College of Medicine (Houston).

"Reprogramming CD4 t cells into cytotoxic CD8 cells by forced expression of CD8ab and class 1 restricted t cell receptors" was invented by Caroline Eva Arber Barth (Houston), Gagan Bajwa (Houston) and Malcolm K. Brenner (Houston).

According to the abstract* released by the U.S. Patent & Trademark Office: "Embodiments of the disclosure include methods and compositions related to improvements of T cell therapy. In particular embodiments, CD8+ T cell therapy is enhanced upon expression of transgenic E08AlphaBeta co-receptor in the CD8+ T cells. In certain embodiments, CD4+ T cells are rendered to have cytoto...