US Patent Issued to BAYER, BAYER PHARMA on May 20 for "Formulation of contrast media and process of preparation thereof" (German Inventors)

ALEXANDRIA, Va., June 16 -- United States Patent no. 12,303,573, issued on May 20, was assigned to BAYER AG (Leverkusen, Germany) and BAYER PHARMA AG (Berlin).

"Formulation of contrast media and process of preparation thereof" was invented by Stephan Holzschuh (Haan, Germany), Thomas Frenzel (Berlin), Gregor Jost (Berlin), Jessica Lohrke (Berlin), Wolfgang Ebert (Krefeld, Germany), Thomas Brumby (Berlin) and Wolfgang Halfbrodt (Berlin).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure relates to a liquid pharmaceutical formulation comprising a DO3A-derived tetra-chelate of formula (I), in which M is an ion of a paramagnetic metal, preferably a Gd3+ ion, and R1, R2, R3, R4 and R5 are as def...