ALEXANDRIA, Va., Nov. 11 -- United States Patent no. 12,466,851, issued on Nov. 11, was assigned to BACHEM HOLDING AG (Bubendorf, Switzerland).
"Manufacture of disulfide bonded peptides" was invented by Ralf Eisenhuth (Basel, Switzerland), Daniel Samson (Leonding, Austria), Ralph O. Schoenleber (Lupsingen, Switzerland) and Patrizia Marchetti (Aarau, Switzerland).
According to the abstract* released by the U.S. Patent & Trademark Office: "A method and apparatus for the manufacture of disulfide bonded peptides is provided, wherein a solution of an oxidizing agent and a solution of a peptide comprising at least two sulfhydryl groups are added simultaneously into a reaction vessel under such conditions that the average concentration of the ox...