US Patent Issued to AUTOLUS on Oct. 28 for "Cytolytic immune cell comprising BCMA- and CD19-specific chimeric antigen receptors" (British Inventors)

ALEXANDRIA, Va., Oct. 28 -- United States Patent no. 12,454,578, issued on Oct. 28, was assigned to AUTOLUS Ltd. (London).

"Cytolytic immune cell comprising BCMA- and CD19-specific chimeric antigen receptors" was invented by Martin Pule (London), Shaun Cordoba (London), Simon Thomas (London), Shimobi Onuoha (London), Mathieu Ferrari (London), Wen Chean Lim (London) and Biao Ma (London).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention provides a chimeric antigen receptor (CAR) which binds a low density target antigen, which comprises a Fab antigen binding domain. The invention also relates to cells expressing such a CAR and their use in the treatment of disease."

The patent was filed on Ma...