ALEXANDRIA, Va., Dec. 9 -- United States Patent no. 12,492,410, issued on Dec. 9, was assigned to AUTOLUS Ltd. (London).
"Engineered cytolytic immunecell" was invented by Shaun Cordoba (London), Shimobi Onuoha (London), Alexander Kinna (London), Simon Thomas (London), Ram Jha (London) and Martin Pule (London).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention relates to engineered a cytolytic immune cell comprising: i) a releasable protein which comprises a polypeptide of interest (POI) and a first interaction domain; and ii) a retention protein which is retained within an intracellular compartment of the cell and comprises a second interaction domain which binds to the first protein interac...