US Patent Issued to Aukera on May 20 for "Methods and compositions for vault nanoparticle immobilization of therapeutic molecules and for vault targeting" (California Inventor)

ALEXANDRIA, Va., June 16 -- United States Patent no. 12,305,200, issued on May 20, was assigned to Aukera Inc. (Whittier, Calif.).

"Methods and compositions for vault nanoparticle immobilization of therapeutic molecules and for vault targeting" was invented by Gayle Boxx (Whittier, Calif.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Described herein are compositions and methods for the immobilization of passenger molecules in a dense matrix of ADP-ribose within the vault particle. The present disclosure also describes a method for altering the physicomechanical properties (e.g. density, compressive strength, electrostatic properties, etc.) of packaged vaults for enhanced stability and/or downstream functio...