ALEXANDRIA, Va., Aug. 26 -- United States Patent no. 12,398,103, issued on Aug. 26, was assigned to Atux Iskay LLC (Plainsboro, N.J.).
"3-diarylmethylenes and uses thereof" was invented by Michael Ohlmeyer (Plainsboro, N.J.).
According to the abstract* released by the U.S. Patent & Trademark Office: "3-Diarylmethylenes are disclosed. The compounds activate PP2A, suppress oncogenic kinase signaling, and negatively regulate MYC and MYCN in cancer. The compounds also induce FOXO transcription factor translocation to the nucleus by modulating PP2A and, as a consequence, exhibit anti-proliferative effects. They are useful in the treatment of a variety of disorders, including as a monotherapy in cancer treatment, or used in combination with oth...