US Patent Issued to AstraZeneca on Sept. 16 for "POLQ inhibitors" (British Inventors)

ALEXANDRIA, Va., Sept. 17 -- United States Patent no. 12,414,954, issued on Sept. 16, was assigned to AstraZeneca AB (Sodertalje, Sweden).

"POLQ inhibitors" was invented by Bernard Barlaam (Cambridge, Great Britain) and Helen Elizabeth Jones (Cambridge, Great Britain).

According to the abstract* released by the U.S. Patent & Trademark Office: "The specification generally relates to compounds of Formula (I):or a stereoisomer or pharmaceutically salt thereof, wherein G, Ga, Gb, X, Y, R1, R2, Q1, Q2, and Q3 have any of the meanings defined herein, together with compositions containing them and their use in therapy. The compounds are inhibitors of the polymerase, DNA polymerase theta (PolTheta or POLQ), and are thereby particularly useful in ...