ALEXANDRIA, Va., Oct. 28 -- United States Patent no. 12,448,385, issued on Oct. 21, was assigned to AstraZeneca AB (Sodertalje, Sweden).

"Substituted indazoles as IRAK4 inhibitors" was invented by Ina Terstiege (Sodertalje, Sweden), Stefan Schiesser (Sodertalje, Sweden), Yafeng Xue (Sodertalje, Sweden), Hui-Fang Chang (Sodertalje, Sweden) and Anna Ingrid Kristina Berggren (Sodertalje, Sweden).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present application relates to chemical compounds of Formula (A), and pharmaceutically acceptable salts thereof, that inhibit IRAK4 and can be used to treat respiratory diseases, cancer, inflammatory diseases, and/or autoinflammatory/autoimmune diseases. Formula (A):R1 a...