ALEXANDRIA, Va., March 19 -- United States Patent no. 12,252,495, issued on March 18, was assigned to AstraZeneca AB (Sodertalje, Sweden).

"Protein kinase B inhibitors" was invented by Paul David Johnson (Macclesfield, Great Britain), Andrew Leach (Macclesfield, Great Britain), Richard William Arthur Luke (Macclesfield, Great Britain), Zbigniew Stanley Matusiak (Macclesfield, Great Britain) and Jeffrey James Morris (Macclesfield, Great Britain).

According to the abstract* released by the U.S. Patent & Trademark Office: "The invention relates to a novel group of compounds of Formula (I) or salts thereof:wherein Y, Z1, Z2, R1, R4, R5 and n are as described in the specification, which may be useful in the treatment or prevention of a disease...