US Patent Issued to Arvinas Operations on Sept. 23 for "Compounds and methods for the targeted degradation of androgen receptor and associated methods of use" (Connecticut Inventor)

ALEXANDRIA, Va., Sept. 23 -- United States Patent no. 12,419,960, issued on Sept. 23, was assigned to Arvinas Operations Inc. (New Haven, Conn.).

"Compounds and methods for the targeted degradation of androgen receptor and associated methods of use" was invented by Lawrence B. Snyder (Killingworth, Conn.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Bifunctional compounds, which find utility as modulators of androgen receptor (AR), are described herein. In particular, the bifunctional compounds of the present disclosure contain on one end a moiety that binds to the cereblon E3 ubiquitin ligase and on the other end a moiety which binds AR, such that the target protein is placed in proximity to the ubiquitin ...