US Patent Issued to Arvinas Operations on Nov. 18 for "Selective modulators of mutant LRRK2 proteolysis and associated methods of use" (Connecticut, New Jersey Inventors)

ALEXANDRIA, Va., Nov. 18 -- United States Patent no. 12,473,294, issued on Nov. 18, was assigned to Arvinas Operations Inc. (New Haven, Conn.).

"Selective modulators of mutant LRRK2 proteolysis and associated methods of use" was invented by Erika Marina Vieira Araujo (Woodbridge, Conn.), Michael Berlin (Flemington, N.J.), Steven M. Sparks (Guilford, Conn.), Jing Wang (Milford, Conn.) and Wei Zhang (Madison, Conn.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Bifunctional compounds, which find utility as modulators of non-receptor Leucine-rich repeat kinase 2 (LRRK2), are described herein. In particular, the bifunctional compounds of the present disclosure contain on one end a moiety that binds to the cerebl...