US Patent Issued to Arvinas Operations on May 27 for "Compounds and methods for the targeted degradation of androgen receptor" (Connecticut, New Jersey Inventors)

ALEXANDRIA, Va., June 17 -- United States Patent no. 12,312,316, issued on May 27, was assigned to Arvinas Operations Inc. (New Haven, Conn.).

"Compounds and methods for the targeted degradation of androgen receptor" was invented by Andrew P. Crew (Chester, Conn.), Hanqing Dong (Madison, Conn.), Xin Chen (Trumbull, Conn.), Yimin Qian (Plainsboro, N.J.) and Lawrence B. Snyder (Killingworth, Conn.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure relates to bifunctional compounds, which find utility to degrade (and inhibit) Androgen Receptor. In particular, the present invention is directed to compounds, which contain on one end a VHL ligand which binds to the ubiquitin ligase and on the ot...